Warren Mosby Seay was born on February 12, 1878, in Fluvanna Co., VA to Burwell Warren Seay, III, and Elizabeth (Bettis) Ann Loving Seay. His early education was received from Rivanna Academy, conducted by his grandfather. He entered Richmond College in 1896 and graduated in 1901. Seay was ordained in 1901, and his first pastorate was at Blackstone, Virginia, before he attended the Southern Baptist Seminary in Louisville, KY. At the Seminary, he earned his Masterís in Theology in 1906 and later his Doctorate in Theoolgy in 1920. After earning his Masterís, he went back to Virginia where he held pastorates at the First Church of Suffolk and then Memorial Baptist Church in Hampton.
Seay was then called in 1912 to be pastor for the First Baptist Church in Russellville, KY and to teach Bible courses at Bethel College. He earned his Doctorate in Divinity from Bethel College in 1915, as well. From there, he went to the Fourth Avenue Church of Louisville in 1917, and then on to The West End Baptist Church in Atlanta, Georgia in 1920. Seay moved from Georgia in 1928 to take over as pastor for the First Church of Anderson in Anderson, South Carolina during the Great Depression. After serving there for nine years, he moved to the First Baptist Church in Beaufort, SC. When his physician ordered him to give up the burdens of a large pastorate, he continued as the Baptist pastor of a Port Royal Baptist Church, a small Union Church in Port Royal, near Beaufort.
Warren Mosby Seay was extremely active outside of his churches as well. He was interim editor for the Baptist Courier, 1947-1948, before Dr. S. H. Jones became editor. Seay served as President of the Home Mission Board of the Southern Baptist Convention from 1925-1928, and also served as Vice-President of the South Carolina State Convention from 1946-1947. He was a trustee for Anderson College from 1928-1939, as well as a trustee for Furman University from 1945-1953. Seay authored five books: A Tale of Two People, The Attitude of Early Christians to Pagan Religions, Jewels of Promise, Christ Triumphant, and The Biography of Baron DeKalb Gray.
On June 11, 1907, Seay married Dorothy Kerr Smith, and they had three daughters. He died October 6, 1952, and is buried in the cemetery of First Baptist Church of Beaufort, SC, where he was pastor emeritus.